This can be used to predict the toxic effects of newly developed substances and existing substances, by testing them on laboratory animals. So this is the most basic and main field of testing. It mainly evaluates the degree and nature of toxicity to pharmaceuticals, health functional foods, cosmetics, agricultural chemicals, industrial products and other environmental pollutants in accordance with GLP Guideline.
General Toxicity Test
The general toxicity test is the most basic and essential toxicity test to predict the toxicity of new test substances in advance.
This provides basic toxicity information such as Approximate Lethal Dose (ALD), No Observed Adverse Effect Level (NOAEL), and Maximum Tolerated Dose Finding Study (MTD). This test is divided into a single (acute) dose toxicity test and a repeated dose (sub-acute and chronic) toxicity test, depending on the duration of the administration.
Field of testing
The general toxicity test is carried out using suitable laboratory animals according to domestic and international regulations (GLP, OECD Guideline, etc) for the toxicity evaluation of various substances such as medicines, cosmetics, health foods, chemicals and pesticides. The following toxicity tests are what we do.
Single dose toxicity test
This test assesses the acute effects in the body through general symptoms, weight changes, and autopsy findings in rats and mice and non-rodents (dogs, primates), and checks the approximate lethal dose. In addition, this test provides the most basic information for other tests, such as repeated dose toxicity testing.
Repeated dose toxicity test
In this test, the test substance is repeatedly administered to rodents (rat, mouse) and non-rodents (dogs, primates) for a certain period of time to evaluate general symptoms, weight changes, hematological and blood biochemical tests, urinalysis, electrocardiogram, autopsy, long-term weighing and histopathological examination. This is to assess toxicity by deriving harmless or non-toxic amounts, target organs and dose-toxicity response relationships.
Tested areas
- - Single dose toxicity test : Oral, transdermal, intravenous, subcutaneous, intradermal, intracutaneous and peritoneal
- - Repeated dose of peritoneal toxicity test : Oral, transdermal, intravenous, subcutaneous, intradermal, intracutaneous and peritoneal
Toxic pathology
The field of toxic pathology is divided into histopathology and clinical pathology.
The field of histopathology confirms morphologically whether the organ tissue is abnormal or not. Clinical pathology quantitatively measures the blood, serum, and electrolytes by analyzing the blood, serum, and urine components by hematology and blood biochemistry. This provides important information in the process of predicting, analyzing and evaluating toxic changes.
Field of testing
Histopathology test
Histopathology test is an important step in the microscopic examination of morphological results for systemic organs in the final stages of toxicity test and efficacy test. We provide step-by-step services ranging from autopsy of various toxicity tests, tissue slide production, microscopic examination and peer review.
Clinical pathology test
In this test, we analyze components such as red blood cells, white blood cells and serum enzyme through hematological and blood biochemical analysis of blood, serum and urine taken during the toxicity test. We use hematology equipment, blood biochemistry equipment, electrolyte equipment, and blood coagulation equipment to analyze and perform reliable tests on the effect of test materials.
Peer Review
In order to increase the reliability of the results of microscopic examination, KTR conducts peer review through domestic and overseas toxicologists, in addition to internal pathologists.
Tested areas
Histopathology test
- Microscopic examination of systemic organs
- Microscopic photography
- Autopsy
- Production histopathological slides by stage (fixing, reprofiling, tissue treatment, embedding, segmentation, dyeing)
Histopathologic slides by stage
Histopathologic slides by stage
| Category |
Sub-category |
Test type |
Test item |
| Blood analysis |
Blood cell analysis |
CBC/DIFF/RETIC |
WBC, RBC, HGB, HCT, MCV, MCH, MCHC, HDW, RDW, PLT, MPV, 6-differential count, Reticulocyte |
| Analysis of blood coagulation time |
Basic test |
aPTT, PT, Fib |
| Preparation of blood smear |
Differentiation of white blood cell |
diff- Quick stain |
| Reticulocyte counting |
New methylene blue stain |
| Reading |
Differential count |
Differential count of white blood cells (neutrophils, eosinophils, basophils, monocytes, lymphocytes) |
| Reticulocyte counting |
Reticulocyte/ 1000 RBC count |
| Red blood cells |
forms, sizes, inclusion bodies, parasites, dyeing property |
| Serum analysis |
Biochemical analysis |
Basic test |
Total protein, Albumin, A/G ratio, Total bilirubin, alanine aminotransferase, aspartate aminotranferase, alkaline phosphatase, creatinine, blood urea nitrogen, total cholesterol, triglyceride, glucose, calcium, phosphorus, γ-glutamyltranspeptidase, creatine kinase |
| Special test |
HDL, LDL, PL, SDH, Bile acid etc |
| Electrolyte analysis |
Basic test |
Na, K, Cl |
| Urine analysis |
Urine chemical analysis |
Basic test |
Leukocyte, Nitrite, Urobilinogen, Urine protein, pH, Occult blood, Specific gravity, Ketone, Bilirubin, Urine glucose |
| Reading |
Urine microscopy examination of white blood cells |
white blood cells, epithelial cells, bacteria, urine cast, crystallization |
| Clinical Pathology Report |
